Powerful high sensitivity, high resolution and fully integrated small animal SPECT/CT system for imaging a wide range of animal species; from mice to monkeys

The nanoScan SPECT/CT is a unique, patented multi-modality system that allows 3D functional imaging of SPECT tracers at sub-half-mm resolution level. The integrated, ultra-fast, low-dose and variable FOV micro-CT provides automatically registered anatomical information for fusion and corrections. The nanoScan SPECT/CT system is a high-speed, high resolution device for both focused and whole body imaging of small animals (e.g. mice and rats, ferrets, minipigs, rabbits, and even smaller non-human primates). The preclinical SPECT/CT system supports quantitative dynamic imaging with full list mode acquisition format. Gated possibilities are offered for both modalities.

Summary of Key Benefits

  • Continuous leadership in preclinical SPECT technology
    • Non-multiplexed M3pinhole™ apertures (multi-pinhole, multi-size, multi-focal), up to 100 pinholes; easily replaceable; whole-body mouse and rat
    • By using 4 large broadband detectors and M3SPECT technology the system offers an outstanding space-bandwidth product1 and detector efficiency further increasing sensitivity and improving spatial resolution.
    • Exceptional performance: Up to 10,000 cps/MBq sensitivity @ sub-millimeter resolution / Up to 0.275 mm resolution
    • Ultra-fast 4D/5D list mode dynamic imaging by static or rotational modes with stationary and helical scans
    • The ONLY system to apply both CT-based attenuation and scatter correction – especially important for quantitative low-energy isotope studies
    • The ONLY small animal SPECT that can image Mice and Monkeys(*)(* with parallel hole collimators)
  • Compact and easy-to-use design
  • CT is used for anatomical reference and enhances SPECT image quality by attenuation and scatter correction

Summary of Key Benefits for SPECT

  • Keeping the development in one hand: Complete detection chain redesigned
    • Mediso Ultra High Performance (UHP) Detector
    • Mediso multi-focal multi-size multiple pinhole apertures(M3-pinhole™)
      • Rectangular apertures have variable aperture size in one plate
      • Multifocal geometry
      • Non-overlapping projections
      • Select the appropriate aperture for the application: whole-body mouse, whole-body rat, ultra-high sensitivity or resolution apertures
      • Fast and easy replacement of apertures

Summary of Key Benefits for CT

The X-ray CT alone is a powerful whole-body imaging system in its own right. Provides the largest variety of species imaging in industry, including larger animals or a whole body mouse scan in one bed position. Offering a very large detector surface and large bore with helical scanning capability, variable zoom (up to 8) and high power X-ray source (up to 80W).

  • Broadest range of CT applications : Ultrafast and ultralow dose CT with variable zoom up to 6 magnification to visualize even the smallest organs or in-vitro samples up to 120mm FOV
    • Perform a whole-body mouse scan in 2 minutes – have the result instantly with 80 micron voxel size
    • Closest source-object distance for in-vivo: extra small objects imaging
  • Tomographic information is ready at the end of a scan*:on the fly, real-time reconstruction is enabled by multi-GPUs (*: for general settings)
  • Lower X-ray exposure dose to animals and faster data acquisition due to stronger X-ray tube, increased detector area, sensitivity and better filtering
  • Fully automated calibration processes
  • Improved safety functions (gantry rotation position is stored, optimized x-ray ramp-up and run-up to ensure prolonged tube lifetime)

System Design

  • Spiral mode with extended axial field of view of 28 cm for both modalities
  • Fully automated animal positioning based on CT scout; manual adjustment is also supported
  • System is equipped with remote access possibility for service and remote diagnostics
  • Safety switches are located in both the acquisition and control room allowing immediate stop of the examination
  • 17” touchscreen monitor on the gantry which allows the user to control bed movements, gantry rotation, positioning for CT zoom and positioning related calibrations as well as settings